Whey kan bekämpa fetma och diabetes typ-2

 

Whey Protein ger stora metabola effekter

I en nyligen publicerad rapport med det långa namnet "Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and Type 2 diabetes" visas att det metabola syndromet med övervikt och diabetes typ-2 förefaller kunna mildras i symtomatologi och omfattning via en regelbunden konsumtion av Whey protein. Effektvägarna är flera, från att öka mättnadskänslan, öka termogenesis d.v.s. kroppens produktion av värme samt via en rad andra potentieringar av molekylära funktionsvägar exempelvis så visar Proteinet Whey(vassleprotein) upp en glukossänkande och insulinotropisk effekt samt påverkar det kraftfulla reglersystemet

 

Konsumtionen av mjölk och mejeriprodukter har förknippats med minskad risk för metabola sjukdomar och hjärt-kärlsjukdomar. Mjölk innehåller två primära proteinkällor, kasein (80 %) och Whey (vassle) (20 %). Nyligen har de gynnsamma fysiologiska effekter av vassleprotein på kontroll av födointag och glukosmetabolismen rapporterats. Studier har visat en insulinotropisk och glukossänkande egenskaper wheyprotein hos friska och typ 2-diabetes patienter. Wheyprotein verkar inducera dessa effekter via bioaktiva peptider och aminosyror som genereras under dess magmatsmältning. Dessa aminosyror och peptider stimulerar frisättningen av flera tarmhormoner såsom kolecystokinin, peptid YY och inkretiner gastrisk hämmande peptid och glukagon-liknande peptid 1 som förstärker insulinutsöndring från β-celler och är förknippade med regleringen av födointag. De bioaktiva peptider genereras från vassleprotein kan också tjäna som endogena hämmare av dipeptidylpeptidas-4 (DPP-4) i den proximala tarmen och förhindrar inkretiner nedbrytning. Faktum nyligen var DPP-4-hämmare identifieras i hydrolysat vassleprotein. Denna översyn kommer att fokusera på de nya egenskaper whey-protein och dess potentiella kliniska effekter vid fetma och typ 2-diabetes.

 

Whey (Vassleprotein) Slutsats

Whey Vassleprotein utöver sin effekt via via bioaktiva peptider och aminosyror som genereras i magen under matsmältning och ökar frisättningen av flera hormoner, såsom CCK, PYY, GIP, GLP-1 och insulin vilka leder till minskat födointag och ökad mättnad (fig. 1). Insulin sekretion är associerad med glukossänkande effekt och med kontroll av födointag. Den mekanism genom vilken vassleproteiner leder till ökad insulinutsöndring är för närvarande inte känd och bör undersökas. En möjlig mekanism är produktionen av bioaktiva peptider som fungerar som endogena inhibitorer av DPP-4 i den proximala tarmen, förhindra nedbrytningen av den insulinotropiska inkretiner GLP-1 och GIP. En annan mekanism kan vara BCAA, speciellt leucin, vilket aktiverar mTOR signalväg och proteinsyntes vilket leder till förhöjda hormon uttryck och sekretion samt en ökad termogenes. Den insulinotropiska effekten av vassleproteiner kan potentiellt dämpa postprandiala variationerna i blodglukosvärdet över dagen och kan därmed förbättra glukoshomeostas i typ 2-diabetes och kan möjligen skjuta upp införandet av medicinsk behandling. Förmågan att amplifiera insulinutsöndring genom vassleprotein kan vara säkrare än de vanligen använda terapeutiska medlen.

 Wheyproteinet ökade på mättnadskänsla såväl som termogenes och visade dessutom fleraförändringar i blodsockerbilden glukoshomeostasen fullt jämförbara med en läkemedelsbehandling vilket stödjer tillämpningen av vassleprotein i den terapeutiska behandlingen av typ 2-diabetes och fetma. Icke desto mindre bör framtida studier avgöra om dessa gynnsamma effekter av vassleprotein på födointag och de subjektiva upplevelserna av mättnadkänsla efter intag hos människa också erhålls också vid ett långvarigt bruk med en daglig konsumtion av vassleprotein.

 

Förkortningar: GMP, glykomakropeptid, DPP-4, dipeptidylpeptidas-4, GIP, glukosberoende insulinotropisk polypeptid, GLP-1, glukagon-liknande peptid-1, BCAA, grenade aminosyror, PYY, peptid YY, CCK, kolecystokinin

Nyckelord: Vassle, diabetes typ-2, fetma, GLP-1, DPP-4, mjölk, Obesitas, Metabolt syndrom

 

Refererande studie om Whey och Diabetes:

Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and Type 2 diabetes.

J Nutr Biochem. 2013 Jan;24(1):1-5. doi: 10.1016 j.jnutbio.2012.07.008.

Jakubowicz D, Froy O. Source Diabetes Unit E. Wolfson Medical Center, Tel Aviv University, Holon 58100, Israel. Electronic address: daniela.jak@gmail.com.

 


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7 mar 2013

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